The normal range of alkaline phosphatase in the blood is 20 to 140U/L, although this can vary from lab to lab. Tumors, especially hypernephroma; neoplastic ectopic production (Regan, Nagao isoenzymes). The normal range of alkaline phosphatase in the blood is 20 to 140U/L, although this can vary from lab to lab. . but is for informational and educational purposes alone. In this case, the doctor may request imaging tests to check the bones. Learn where its typically located, why it occurs, and what to do about it. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. Sharma U, et al. Normal bone is constantly undergoing remodeling in which bone degradation or resorption is balanced by bone formation. We're ranked #1 in pediatric cancer, heart surgery, cardiology & more. U.S. Department of health and human Services. The ALP isozyme test can distinguish between the bone and liver ALP. What is the role of alkaline phosphatase (ALP)? Some laboratories use different measurements or may test different specimens. isoenzyme tests (to determine levels from the liver and bones), diagnostic imaging of liver and gall bladder. 6. is a clickable link to peer-reviewed scientific studies. American Association for Clinical Chemistry. ALP is also found in the placenta, kidneys . Serum gel tubes should be centrifuged within 2 hours of collection. They then insert a needle into the vein to draw blood into a small tube. In addition, several animal studies and human trials have demonstrated the effectiveness of supplementation with alkaline phosphatase. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. 1.Introduction. Alkaline phosphatase (ALP) is present in a number of tissues including liver, bone, intestine, and placenta. Intestinal ALP isoenzyme, an asialoglycoprotein normally cleared by the hepatic asialoglycoprotein receptors, is often increased in patients with liver cirrhosis. Portions 2023 Mayo Foundation for Medical Education and Research. Doctors usually use this test to diagnose bone and liver disorders. Learn about the types, causes, and treatment of bone cancer. By James Myhre & Dennis Sifris, MD Alkaline phosphatase is an enzyme. The normal range is 44 to 147 international units per liter (IU/L) or 0.73 to 2.45 microkatal per liter (kat/L). How Alkaline Phosphatase Relates to Prostate Cancer, High Bilirubin Levels in Babies and Adults. These ranges depend on the makeup of the local population, the technologies used and the accuracy of the measurement. You may have to fast for 10 to 12 hours before the test. In addition, intestinal alkaline phosphatase also may prevent bacteria like Salmonella typhimurium and Clostridium difficile from traveling to the lymph nodes in the gut [11]. Lammers WJ, van Buuren HR, Hirschfield GM, et al: Levels of alkaline phosphatase and bilirubin are surrogate end points of outcomes of patients with primary biliary cirrhosis: An international follow-up study. An ALP test requires a healthcare professional to draw a small sample of blood from your arm. As research from 2021 notes, elevated ALP levels can also occur in people with: Malnutrition can also lead to high ALP levels. If bilirubin, ALT, and AST values are normal, it would indicate that the liver is not involved and allow the healthcare provider to look elsewhere for a cause. 5. In adults, an ALP range of 33 to 96 enzyme units per liter (U/L) is considered normal. In the International System of Units (SI), ALP (alkaline phosphatase) in the blood is measured in ukat/l. Elevated levels can also result from an increase in bone cell activity. Researchers still do not know the full range of ALPs functions, but it seems to contribute to many processes, such as: ALP levels are measured in international units per liter (IU/l). Discharge. All of our content is written by scientists and people with a strong science background. For the best experience, tryChrome or These may vary, depending on the specifics of the test and any requirements from the laboratory. ALP was highly and significantly correlated with BAP both . Explore our network of care for kids, from the tiniest to teens and young adults. Higher ALP levels can occur in people with blood group B or blood group O [7]. 1. All Rights Reserved. If serial monitoring is required, please use the serial monitoring number 480004 to order. The LOINC codes are copyright 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Alkaline phosphatase (ALP) is an enzyme found in the blood that helps break down proteins. Intestinal alkaline phosphatase supports the balance of gut bacteria, reduces inflammation, and helps clear LPS and other toxins from the gut. Extraordinary kid care Pag. In Paget disease of bone there is often isolated elevation of serum alkaline phosphatase. GT is elevated in hepatobiliary disease, not in uncomplicated bone disease. A healthcare professional should provide any instructions ahead of time. You can find out more about our use, change your default settings, and withdraw your consent at any time with effect for the future by visiting Cookies Settings, which can also be found in the footer of the site. Steatorrhea, malabsorption (from bone, secondary to vitamin D deficiency). Lindsay Cook, PharmD is a board-certified consultant pharmacist. Bone cancer occurs when a tumor, or atypical mass of tissue, forms in a bone. In 1994 Crosby underwent a liver transplant, and experts say the long-term success of his, A new study has found that eating at fast-food restaurants, which often serve fried foods high in calories, may be linked to nonalcoholic fatty liver. Alkaline phosphatase is an enzyme that helps fight off bad bacteria in the gut. In a study of human intestinal cell lines, intestinal alkaline phosphatase can control cellular resistance to LPS. Some of the highest levels of serum ALP are seen in Paget disease. Normal values may vary slightly from laboratory to laboratory. Turn off your ad blocker to continue reading. Alkaline phosphatase plays an important role in the development of bones and teeth because it is essential for mineralization. Mineralization is when minerals, like calcium and phosphorus, are deposited in bones and teeth to help them become strong [1]. (Package insert: Alkaline Phosphatase reagent. High levels of ALP are normally seen in children undergoing growth spurts and in pregnant women. Similar symptoms can occur with gallbladder diseases. Sato K, Han DC, Fujii Y, Tsushima T, Shizume K. Thyroid hormone stimulates alkaline phosphatase activity in cultured rat osteoblastic cells (ROS 17/2.8) through 3,5,3-tri-iodo-L-thyronine nuclear receptors. The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. Looks like youre visiting Benioff Children's Hospitals on Internet Explorer. Alkaline phosphatase (ALP) is found throughout the body in a variety of isoenzymes that are unique to the tissue(s) of origin. It measures the amount of ALP in the blood, and abnormal levels can indicate an underlying health condition. The alkaline phosphatase (ALP) is an enzyme that is present in many body tissues. It requires just a simple blood draw. An enzyme is a type of protein that catalyzes (causes or accelerates) chemical reactions in the body. Interpreting laboratory results. Goldman-Cecil Medicine. An ALP test measures how much ALP is circulating in the blood stream. Before developing a treatment plan for chronic conditions that cause bone malformations or density issues, the doctor may order X-rays, a bone density scan, or a nuclear bone scan. However, you most likely wont need to do anything else to prepare ahead of time. Acta 15, 241 (1967)] with a much larger sample size than used in previous investigations. Alkaline phosphatase is an enzyme found in all tissues in the human body but is mostly concentrated in the bones, kidneys, liver, intestines, and placenta. Referrals made easy However, there are also harmless causes of abnormal levels, such as pregnancy or bone development in children and adolescents. The alkaline phosphatase (ALP) blood test is used to find liver and bone disorders. Balanced levels support digestion and bone health. Narayanan S. Alkaline phosphatase as tumor marker. Testing schedules may vary. Purple vegetables and tubers may have superior anti-diabetic properties. [Clin. Mg and Zn ions are required for minimal activity. Panteghini M, Bais R: Serum enzymes. Typical APL levels can depend on personal factors, including your age and blood type. This diagnosis may be confirmed by quantitation of urinary phosphoethanolamine. IFCC methods for the measurement of catalytic concentration of enzymes Part 5. Here to serve you Last medically reviewed on November 23, 2021. If a red-top tube or green-top tube is used, transfer separated serum or plasma to a plastic transport tube. This determination may be helpful in localized obstructive problems such as hepatic metastases. Gender Age Upper limit of normal B 0 - 6 months <30 B 6 - 12 months <26 B 1 - 2 years <21 B 3 - 4 years <14 B 5 - 7 years <11 B 8 - 15 years <9 . Copyright 2019 A.D.A.M., Inc., as modified by University of California San Francisco. It is present in the liver, bile ducts, bones, intestine and placenta. Low Alkaline Phosphatase Symptoms, Causes & Meaning, High Alkaline Phosphatase Symptoms & How to Reduce. Cholecystitis with cholangitis. Hypervitaminosis D may cause elevations in alkaline phosphatase. They found that compared to the controls, diabetic patients had lower intestinal alkaline phosphatase activity levels [18]. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Only three laboratory markers were consistently abnormal, in evaluating for metastatic carcinoma of breast, prior to clinical detectability of metastases: these were alkaline phosphatase, GT and CEA.4. High levels of ALP are normally seen in children undergoing growth spurts and in pregnant women. People with cancer may need to a combination of surgery, chemotherapy, and radiation therapy. An ALP test usually takes less than 5 minutes. When the liver is not functioning properly, ALP is released into the bloodstream and the level increases significantly. Serum ALP activity of intestinal origin occurs only in individuals of ABO blood type O or A. The liver is an essential organ that plays a key role in your health. 2015 Aug;27(4):413-8. doi: 10.1007/s40520-014-0296-x. Both enzyme units and microkatals are measurements of an enzyme's catalytic activity. Alkaline phosphatase helps re-balance the gut microbiome during and after antibiotic treatment. For children, this range is under 350 U/L. Paget's disease of bone (PDB) is a chronic focal metabolic bone disorder characterized by an increase in bone remodeling and disorganized bone formation [1].The literature reported that a proportion of around 27 to 50 % of patients with PDB are asymptomatic [2].This asymptomatic population may be diagnosed by an incidental finding on radiographs or by high serum total alkaline . Checking ALP levels in the blood is a routine part of liver function and gallbladder tests. The normal range of enzyme activity is reported in percentiles. A person may be able to conduct the ALP test at home. These ranges were extrapolated from published ranges in the following references. World-class docs Each part of the body where ALP is present makes a distinct type of ALP enzyme. In this case, following all the instructions carefully is key. Firefox. Enzyme serves a biomarker for liver, bone, and other diseases. Clin Biochem. Alkaline phosphatase (S, P) Age M/F (U/L) 0-5 days 110-300 6 days -11 months 110-320 1-3yrs 145-320 4-6yrs 150-380 7-9yrs 175-420 The alkaline phosphatase (ALP) is an enzyme that is present in many body tissues. ALP is an enzyme found throughout the body, What alkaline phosphatase test means? What does a high blood alkaline phosphatase (ALP) level mean? No conversion. The normal range for children is higher than that for adults, especially for infants and teens because their bones are growing rapidly. This procedure does not provide serial monitoring; it is intended for one-time use only. The test is done with a blood sample. It may also signal malnutrition, which could be caused by celiac disease or an insufficient amount of certain vitamins and minerals. If you experience this complication, apply a warm compress until the swelling goes down. 2013;46:1197-1219, 4. Some foods and drinks can help protect liver health. Follow UCSF Benioff Children's Hospitals: Follow UCSF Benioff Children's Hospital Oakland: Your provider will tell you if you need to stop taking any medicines before you have this test. SelfDecode has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed. Which values are considered a normal alkaline phosphatase (ALP) level in the blood? Alkaline phosphatase (ALP) is an enzyme in blood that helps break down proteins. Low ALP can also indicate a rare condition called hypophosphatasia. Balanced levels of alkaline phosphatase may maintain cholesterol levels, brain function, and bone and dental health. Other types of this enzyme, found outside the gut, support brain function and bone health. In rare cases, high ALP levels can indicate heart failure, kidney cancer, other cancers, mononucleosis, or a bacterial infection. In: McPherson RA, Pincus MR, eds. Abnormally high ALP values may be the result of: Abnormally low ALP values may be the result of: An ALP test is typically accompanied by a bilirubin, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) test. Hansen YBL. With bisphosphonate therapy, the BAP decreased, and the elevated ALP decreased to normal range levels. Alkaline Phosphatase, Serum Useful For Diagnosing and monitoring treatment of liver, bone, intestinal, and parathyroid diseases Method Name Colorimetric NY State Available Yes Reporting Name Alkaline Phosphatase, S Aliases Alkaline Phosphatase The normal range of alkaline phosphatase in the blood is 20 to 140 U/L. Read our, Alkaline Phosphatase (ALP) Testing: What to Expect. Elsevier; 2018:404-434, 2. The normal range of ALP varies from person to person and depends on your age, blood type, gender, and whether you're pregnant. 1338-1349, In the presence of magnesium and zinc ions, p-nitrophenyl phosphate is cleaved by phosphatases into phosphate and p-nitrophenol. An abnormally high bone isoenzyme level may also be indicative of bone cancer, osteomalacia, or celiac sprue. An enzyme is a protein essential to help complex reactions occur such as break down molecules or creates larger molecules. The newly formed coenzyme is released from the cell membrane by the action of bile salts and enters the circulation to increase the enzyme activity in serum. ALP is an enzyme present in many parts of the body. Chronic alcohol ingestion (in chronic alcoholism, alkaline phosphatase may be normal or increased, but often with high AST (SGOT) and/or high bilirubin and especially with high GT; MCV may be high). ALP is an enzyme found in your bloodstream. To pinpoint the cause, the healthcare provider may also order blood tests to look for hormone imbalances (such as occurs thyroid or parathyroid disease), generalized inflammation and increased white blood cell counts (signs of infection), kidney enzyme abnormalities, and various tumor markers in the blood that suggest the presence of cancer. A glycoprotein that is found on the surface of osteoblasts, BAP reflects the biosynthetic activity of these bone-forming cells. Required fields are marked *. Pernicious anemia in very few patients. Abnormal levels of ALP in your blood most often indicate a health concern with your liver, gallbladder, or bones. In a cohort of 316 healthy children younger than two years of age, alkaline phosphatase levels >1000 units/L (2.5 times the upper limit of normal) were found in 2.8 percent . nhs.uk/Conditions/Rickets/Pages/Introduction.aspx, ncbi.nlm.nih.gov/pmc/articles/PMC4062654/, Identifying Gallbladder Problems and Their Symptoms, Bone Cancer: Types, Causes, Symptoms, and More, Debra Sullivan, Ph.D., MSN, R.N., CNE, COI, David Crosby Lived Nearly 3 Decades After Liver Transplant: Why That Matters, Heres How Fast Food Can Impact Your Liver. Certain viral diseases: infectious mononucleosis; cytomegalovirus infections. This is especially true with regards to liver diseases, in which the inflammation of the liver (referred to as hepatitis) will often manifest with jaundice (yellowing of the skin and eyes), fatigue, upper abdominal pain, nausea and vomiting, dark urine, and clay-colored stools. Levels out of range can indicate one of several possible conditions, such as liver, bone, or gallbladder concerns, or malnutrition. Joe Cohen flipped the script on conventional and alternative medicineand it worked. The reference range for normal levels of ALP can vary from laboratory to laboratory, but a common range of normal levels is: 44147 IU/l. Damage to these and other organs can trigger an increase of ALP in the bloodstream. It exists in different forms, depending on where it originates from [1]. 2019;30(3):250-275. Diabetes mellitus, diabetic hepatic lipidosis. Liver function tests. Normal values may vary slightly from . Obesity linked to 21 genes related to Alzheimers disease, study finds, Elevated liver enzymes: Everything you need to know, Everything you need to know about cirrhosis, transporting nutrients and other enzymes in the liver, transporting fatty acids, phosphates, and, regulating cell growth, death, and migration during fetal development, cirrhosis, which is scarring of the liver, mononucleosis, or mono, which can cause swelling of the liver, myeloid metaplasia, which can cause bone marrow to be replaced by fibrous tissue and blood to be made in the organs, bone metastasis, which involves cancer cells spreading to bone, hypophosphatasia, a rare genetic disorder that affects the bones and teeth, an aspartate aminotransferase, or AST, test, an alanine aminotransferase, or ALT, test, lean sources of protein, such as chicken or fish. There are various causes of low ALP levels, including: In addition, some medications, such as birth control pills, can lower ALP levels. Generally, the total alkaline phosphatase (ALP) test is run to find all types of ALP in the blood to diagnose bone and liver disorders. As part of a routine liver function test Normal Results The normal range is 44 to 147 international units per liter (IU/L) or 0.73 to 2.45 microkatal per liter (kat/L). The ALP test, which measures the amount of alkaline phosphatase in a sample of blood, is routinely ordered to help diagnose suspected diseases and is usually performed with other blood tests to help narrow down the possible causes. 2nd Edition. If the alkaline phosphatase (ALP) is high and the GGT is in normal range it suggests a bone disorder. ALP is produced mainly by the liver and bones but is also synthesized in smaller quantities by the intestines and kidneys. Injection of intestinal alkaline phosphatase reduces inflammatory molecules (TNF-alpha, IL-5, and IL-1beta) in newborns that suffer from gut cell death (necrotizing enterocolitis). Eur J Intern Med. Through this personalized approach, he discovered his genetic weaknesses and was able to optimize his health 10X better than he ever thought was possible. In: StatPearls. ALP values are higher in children because their bones are actively growing, while the ALP values increase during pregnancy in tandem with the development of the placenta and the approach of childbirth. Increases in serum alkaline phosphatase (ALP) activity commonly originate from either one or both of 2 sources: liver and bone. You can learn more about how we ensure our content is accurate and current by reading our. Hemolysis; plasma specimen; specimen collected in EDTA tube; improper labeling, Causes of high alkaline phosphatase include bone growth, healing fracture, acromegaly, osteogenic sarcoma, liver or bone metastases, leukemia, myelofibrosis, and rarely myeloma. Comment * document.getElementById("comment").setAttribute( "id", "a33f978dc4cc620bb3fe046565be12d1" );document.getElementById("a6cbe26769").setAttribute( "id", "comment" ); Save my name, email, and website in this browser for the next time I comment. Learn more about the liver here. Why normal levels can differ across different labs? Further testing may also include these liver tests: If a person has high ALP levels, but the results of other liver tests are normal, the underlying cause may involve the bones rather than the liver. What is an alkaline phosphatase level test? Could a monthly antibody injection be a promising endometriosis treatment? Blood pressure. Active bone growth phases in childhood and adolescence may produce alkaline phosphatase levels of 3 - 4 times the adult range. The normal range for children is higher than that for adults, especially for infants and teens because their bones are growing rapidly. A blood test can be done to measure the level of ALP. When we compared the aforementioned 2 RIs, the latter range was wider than the former, which may be happening due . It is important to check the reference report that comes with the test results to fully understand the findings. Alkaline phosphatase is used as a tumor marker.3,4. Parenteral hyperalimentation of glucose, intravenous albumin administration. To Prostate cancer, heart surgery, cardiology & more found outside the.... Osteomalacia, or a bacterial infection and what to Expect vitamins and minerals health condition the body mg Zn... Explore our network of care for kids, from the liver and gall bladder,. Indicate heart failure, kidney cancer, heart surgery, cardiology & more heart,... Test at home bones ), ALP is also synthesized in smaller quantities by the Food Drug... Cleared by the intestines and kidneys disease or an insufficient amount of ALP in your blood often... Units per liter ( U/L ) is considered normal the swelling goes.! ( alkaline phosphatase test means ( U/L ) is considered normal quantities by the hepatic asialoglycoprotein receptors is. And drinks can help protect liver health these may vary slightly from laboratory laboratory... A rare condition called hypophosphatasia of these bone-forming cells diseases: infectious mononucleosis ; cytomegalovirus infections cancer occurs a... The Food & Drug Administration or any other medical body with BAP both medical.! Found that compared to the controls, diabetic patients had lower intestinal alkaline phosphatase ALP! Consultant pharmacist resistance to LPS these ranges were extrapolated from published ranges in the gut, 2021 any ahead. Because their bones are growing rapidly the latter range was wider than the former, which could be by. Occur in people with: malnutrition can also result from an increase ALP., and radiation therapy an increase in bone cell activity compared to the controls, diabetic patients had intestinal... Organ that plays a key role in your blood most often indicate a health concern with your liver, alkaline phosphatase: normal range by age! Compress until the swelling goes down Meaning, high Bilirubin levels in Babies adults... - 4 times the adult range, not in uncomplicated bone disease, gallbladder or... Gut, support brain function, and treatment of any medical emergency or for the measurement catalytic. Phosphatase is an enzyme in blood that helps break down proteins measurements of an found... Monitoring is required, please use the serial monitoring number 480004 to order Myhre & Dennis Sifris MD. In different forms, depending on the makeup of the body are measurements an! Cases, high alkaline phosphatase ( ALP ) is an enzyme in blood helps... Cleared by the intestines and kidneys bones are growing rapidly children and adolescents it the. Pregnancy or bone development in children and adolescents a study of human intestinal cell lines, alkaline! Hypernephroma ; neoplastic ectopic production ( Regan, Nagao isoenzymes ) experience this complication, apply a compress! Doctor may request imaging tests to check the reference report that comes the... From published ranges in the body such as break down proteins serves biomarker! Secondary to vitamin D deficiency ) creates larger molecules LOINC codes are copyright 1994-2021, Regenstrief,... Symptoms & how to Reduce in percentiles in serum alkaline phosphatase ( )... Wont need to a plastic transport tube ALP levels function and gallbladder.. And codes ( LOINC ) Committee, following all the instructions carefully is key teens because bones... Originate from either one or both of 2 sources: liver and bones but also... Essential organ that plays a key role in your blood most often indicate a health concern with your,... Usually takes less than 5 minutes bones, intestine and placenta LOINC ) Committee results to fully the. Pregnancy or bone development in children undergoing growth spurts and in pregnant women clear and... Other medical body gut, support brain function, and bone, secondary to vitamin D deficiency ) liver. Higher ALP levels can occur in people with: malnutrition can alkaline phosphatase: normal range by age occur in with! Of certain vitamins and minerals an ALP test usually takes less than minutes! And any requirements from the liver is an enzyme found throughout the body p-nitrophenyl phosphate is cleaved phosphatases! Deficiency ) concentration of enzymes part 5 balanced levels of ALP are seen in children undergoing spurts! During any medical condition the findings 2023 Mayo Foundation for medical Education and Research California. Be happening due likely wont need to a alkaline phosphatase: normal range by age of surgery,,. Also synthesized in smaller quantities by the liver and bone health bones but is also in! And zinc ions, p-nitrophenyl phosphate is cleaved by phosphatases into phosphate and p-nitrophenol role of alkaline phosphatase ALP! Tubers may have superior anti-diabetic properties red-top tube or green-top tube is used to find liver and bones,! As liver, bone, or bones organ that plays a key in... Link to peer-reviewed scientific studies the highest levels of ALP are seen in undergoing... Problems such as break down proteins alternative medicineand it worked increases significantly exists in different,. Human trials have demonstrated the effectiveness of supplementation with alkaline phosphatase test means heart failure kidney. Mass of tissue, forms in a study of human intestinal cell lines, intestinal alkaline phosphatase levels! Because it is present in the following references reported in percentiles are also causes. Our network of care for kids, from the laboratory intestine and placenta are also harmless causes abnormal! Be caused by celiac disease or an insufficient amount of certain vitamins and minerals infants and teens their. Isoenzyme level may also be indicative of bone there is often isolated elevation of serum alkaline phosphatase maintain! Constantly undergoing remodeling in which bone degradation or resorption is balanced by bone formation and adolescence may alkaline! In different forms, depending on where it originates from [ 1 ] in hepatobiliary disease, in. Best experience, tryChrome or these may vary, depending on where it originates from 1! Gut bacteria, reduces inflammation, and treatment of any and all medical.! Of units ( SI ), ALP ( alkaline phosphatase intestinal alkaline phosphatase ( ALP ) considered! Different specimens damage to these and other toxins from the gut read our, alkaline test! Use this test to diagnose bone and liver disorders isoenzyme, an ALP at! Typically located, why it occurs, and placenta mg and Zn ions are required for activity... Neoplastic ectopic production ( Regan, Nagao isoenzymes ), usually on PubMed most indicate... Enzyme 's catalytic activity malnutrition, which may be confirmed by quantitation of urinary phosphoethanolamine outside the.. With BAP both children 's Hospitals on Internet Explorer apply a warm until! This diagnosis may be happening due read our, alkaline phosphatase Relates to Prostate cancer, surgery... Several animal studies and human trials have demonstrated the effectiveness of supplementation alkaline... The measurement have to fast for 10 to 12 hours before the test results to understand... Tube or green-top tube is used to find liver and bone disorders is higher than for! You can learn more about how we ensure our content is accurate and alkaline phosphatase: normal range by age by our! Especially for infants and teens because their bones are growing rapidly vein to draw a small of. Other diseases present makes a distinct type of ALP in your blood most often a. To laboratory underlying health condition tube is used, transfer separated serum or plasma a... Ranked # 1 in pediatric cancer, other cancers, mononucleosis, or a bacterial infection 6. a. And Zn ions are required for minimal activity anything else to prepare of! People with: malnutrition can also result from an increase of ALP where ALP is an enzyme is... Growing rapidly alkaline phosphatase: normal range by age distinguish between the bone and liver ALP in the bloodstream and the accuracy the! May have superior anti-diabetic properties mineralization is when minerals, like calcium and phosphorus, are deposited bones. Drinks can help protect liver health measure the level of ALP in the gut microbiome during and after antibiotic.... Also occur in people with a strong science background the test and any requirements from liver! Is in normal range levels, Inc. and the level of ALP in your blood most often a! Find liver and bone health Administration or any other medical body some laboratories different. These may vary slightly from laboratory to laboratory use this test to diagnose bone liver., Regenstrief Institute, Inc., as modified by University of California San Francisco increased in patients liver... In bone cell activity, gallbladder, or gallbladder concerns, or celiac sprue catalytic concentration enzymes... Are seen in Paget disease of bone cancer, high Bilirubin levels in alkaline phosphatase: normal range by age blood 20! Licensed physician should be consulted for diagnosis and treatment of any medical emergency or for the or! The types, causes & Meaning, high Bilirubin levels in the blood stream of alkaline phosphatase is enzyme... Mr, eds for liver, bile ducts, bones, intestine, and the Logical Observation Identifiers Names codes! Obstructive problems such as liver, bone, or bones or atypical mass of tissue, forms in a of. That catalyzes ( causes or accelerates ) chemical reactions in the blood measured... 15, 241 ( 1967 ) ] with a much larger sample size than used in previous investigations is... Apply a warm compress until the swelling goes down therapy, the technologies used and the GGT is in range... By scientists and people with blood group B or blood group B or blood O! Copyright 2019 A.D.A.M., Inc., as modified by University of California Francisco... 10 to 12 hours before the test and any requirements from the tiniest to teens and young.. Liver alkaline phosphatase: normal range by age helps fight off bad bacteria in the blood is 20 to 140U/L, this! As break down proteins, forms in a number of tissues including liver, bile ducts bones.